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Roughly half of a dose of amphetamine undergoes oxidation to metabolites by hepatic P-450 metabolism (2D6), while the remainder is cleared by the kidney

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Instead, it is more appropriate to envision metabolic plasticity regarding uptake of alternative metabolic substrates and promotion of metabolic rewiring as a built-in feature that has evolved to allow cancer cells to constantly adapt to changing intracellular- and extracellular metabolic conditions 2